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Successful outcome of disseminated mucormycosis in a 3-year-old child suffering from acute leukaemia: the role of isavuconazole? A case report.

Abstract : BACKGROUND: The use of isavuconazole is approved for the management of invasive aspergillosis and mucormycosis, only in adults, as no paediatric pharmacology studies have been reported to date. Very few paediatric cases have been published concerning the use of isavuconazole. Amphotericin B is the only antifungal agent recommended in paediatric mucormycosis, but adverse effects and especially nephrotoxicity, even with the liposomal formulation, could be problematic. In this context, the use of other antifungal molecules active on Mucorales becomes needful. METHODS: We describe a case of mucormycosis with rapid onset dissemination in a 3-year-old girl recently diagnosed with acute lymphocytic leukaemia. She was successfully treated with isavuconazole alone and then in combination with liposomal amphotericin B. Isavuconazole therapy was guided by therapeutic drug monitoring. CONCLUSIONS: This case offers new perspectives on the potential use of isavuconazole in children with mucormycosis, as an alternative or adjunct to liposomal amphotericin B.
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Contributeur : Lilloa Université de Lille <>
Soumis le : vendredi 20 mars 2020 - 17:48:43
Dernière modification le : mardi 24 mars 2020 - 01:42:14

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Marjorie Cornu, Benedicte Bruno, Severine Loridant, Pauline Navarin, Nadine Francois, et al.. Successful outcome of disseminated mucormycosis in a 3-year-old child suffering from acute leukaemia: the role of isavuconazole? A case report.. BMC Pharmacology and Toxicology, BioMed Central, 2018, 19, pp.81. ⟨10.1186/s40360-018-0273-7⟩. ⟨hal-02513581⟩

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