OBJECTIVE: To summarize significant research contributions on human factors (HF) and organizational issues in medical informatics published in 2018. METHODS: An extensive search using PubMed/Medline and Web of Science® RESULTS: The four selected best papers are excellent contributions to the HF literature: they show the added value of HF studies by providing nice illustrated and rigorous interventions. CONCLUSIONS: HF interventions are known to have great potential to contribute to efficient HIT design, but the interventions still face challenges in successfully demonstrating their value to the main stakeholders of the healthcare domain. There is a need to strengthen the demand for high-quality HF studies by increasing awareness among powerful stakeholders of the value of high-quality HF studies.