OBJECTIVE:  To summarize significant research contributions published in 2017 on Human Factors and Organizational Issues (HFOI) in medical informatics. METHODS:  An extensive search using PubMed/Medline and Web of Science® RESULTS:  The five best papers offer a glimpse of the quality and breadth of the work being conducted in the HFOI community. CONCLUSIONS:  The selection of the HFOI section of the 2018 IMIA Yearbook highlights a growing number of high quality studies. There are especially more studies interested in testing Human Factors and Ergonomics methods and demonstrating the benefits.