Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

O-GlcNAcylation as a regulator of the functional and structural properties of the sarcomere in skeletal muscle: an update review.

Abstract : Although the O-GlcNAcylation process was discovered in 1984, its potential role in the physiology and physiopathology of skeletal muscle only emerged 20 years later. An increasing number of publications strongly support a key role of O-GlcNAcylation in the modulation of important cellular processes which are essential for skeletal muscle functions. Indeed, over a thousand of O-GlcNAcylated proteins have been identified within skeletal muscle since 2004, which belong to various classes of proteins, including sarcomeric proteins. In this review, we focused on these myofibrillar proteins, including contractile and structural proteins. Because of the modification of motor and regulatory proteins, the regulatory myosin light chain (MLC2) is related to several reports that support a key role of O-GlcNAcylation in the fine modulation of calcium activation parameters of skeletal muscle fibres, depending on muscle phenotype and muscle work. In addition, another key function of O-GlcNAcylation has recently emerged in the regulation of organization and reorganization of the sarcomere. Altogether, this data support a key role of O-GlcNAcylation in the homeostasis of sarcomeric cytoskeleton, known to be disturbed in many related muscle disorders.
Type de document :
Article dans une revue
Liste complète des métadonnées

Littérature citée [110 références]  Voir  Masquer  Télécharger

https://hal.univ-lille.fr/hal-02539522
Contributeur : Lilloa Université de Lille <>
Soumis le : vendredi 10 avril 2020 - 10:42:59
Dernière modification le : mercredi 15 avril 2020 - 01:31:54

Fichier

Acta Physiol 2019.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Matthias Lambert, Charlotte Claeyssen, Bruno Bastide, Caroline Cieniewski. O-GlcNAcylation as a regulator of the functional and structural properties of the sarcomere in skeletal muscle: an update review.. Acta Physiologica, Wiley, 2019, 228 (1), pp.e13301. ⟨10.1111/apha.13301⟩. ⟨hal-02539522⟩

Partager

Métriques

Consultations de la notice

38

Téléchargements de fichiers

78