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Th17 and cd24(hi)cd27(+) regulatory b lymphocytes are biomarkers of response to biologics in rheumatoid arthritis

Abstract : The aim was to describe the regulatory B and T cells (Breg and Treg) and T helper 17 (Th17) lymphocytes before and under treatment with biologic drugs, and to assess their potential predictive value as biomarkers of response in rheumatoid arthritis (RA). This was a non-randomised, single-centre, prospective study. Patients with active RA (American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) 2010) who required the initiation or switch to any biologic drug except rituximab were included. The main judgement criterion was the frequency and absolute number of CD24hi+hihihilow-++ Thirty-one patients with RA and 17 controls were included. There was a reduction in T2/Breg frequency at M0 in patients (p < 0.001) and absolute numbers (p = 0.014) and in immunopositive vs. immunonegative RA (p = 0.016). DAS28 remission at M6 was associated with increased frequency of Treg (p = 0.01). A higher level of CD24hi+ Altogether, these data, although preliminary, suggest that phenotyping of T and B cells has potential value for the stratification of biologic drugs, notably with respect to choosing between abatacept and anti-cytokine blockade.
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Soumis le : jeudi 16 avril 2020 - 10:51:33
Dernière modification le : vendredi 17 avril 2020 - 01:00:38

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Sarah Salomon, Caroline Guignant, Pierre Morel, Gauthier Flahaut, Clement Brault, et al.. Th17 and cd24(hi)cd27(+) regulatory b lymphocytes are biomarkers of response to biologics in rheumatoid arthritis. Arthritis Research and Therapy, BioMed Central, 2017, 19, pp.33. ⟨10.1186/s13075-017-1244-x⟩. ⟨hal-02544267⟩

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