Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

MRI of the cervical spinal cord predicts respiratory dysfunction in ALS

Abstract : For patients with amyotrophic lateral sclerosis (ALS), the primary therapeutic goal is to minimize morbidity. Non-invasive ventilation improves survival. We aim to assess whether Magnetic Resonance Imaging (MRI) of the cervical spinal cord predicts the progression of respiratory disorders in ALS. Brain and spinal MRI was repeatedly performed in the SOD1G86R mouse model, in 40 patients and in healthy controls. Atrophy, iron overload, white matter diffusivity and neuronal loss were assessed. In Superoxide Dismutase-1 (SOD1) mice, iron accumulation appeared in the cervical spinal cord at symptom onset but disappeared with disease progression (after the onset of atrophy). In ALS patients, the volumes of the motor cortex and the medulla oblongata were already abnormally low at the time of diagnosis. Baseline diffusivity in the internal capsule was predictive of functional handicap. The decrease in cervical spinal cord volume from diagnosis to 3 months was predictive of the change in slow vital capacity at 12 months. MRI revealed marked abnormalities at the time of ALS diagnosis. Early atrophy of the cervical spinal cord may predict the progression of respiratory disorders, and so may be of value in patient care and as a primary endpoint in pilot neuroprotection studies.
Liste complète des métadonnées

Littérature citée [12 références]  Voir  Masquer  Télécharger

https://hal.univ-lille.fr/hal-02565103
Contributeur : Lilloa Université de Lille <>
Soumis le : mercredi 6 mai 2020 - 10:51:50
Dernière modification le : jeudi 20 août 2020 - 03:05:45

Fichier

s41598-018-19938-2.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Collections

Citation

Guillaume Grolez, Maéva Kyheng, Renaud Lopes, Caroline Moreau, Kelly Timmerman, et al.. MRI of the cervical spinal cord predicts respiratory dysfunction in ALS. Scientific Reports, Nature Publishing Group, 2018, 8, pp.1828. ⟨10.1038/s41598-018-19938-2⟩. ⟨hal-02565103⟩

Partager

Métriques

Consultations de la notice

52

Téléchargements de fichiers

51