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Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP

Abstract : A new method for determining solubility lines of drugs in polymers, based on low-frequency Raman spectroscopy measurements, is described and the results obtained by this method are compared with those obtained using a more classical method based on differential scanning calorimetry investigations. This method was applied to the paracetamol/PVP system using molecular and crystalline dispersions (MCD) rather than usual physical mixtures to reach faster the equilibrium saturated states and make the determination of the solubility line more rapid.
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https://hal.univ-lille.fr/hal-02967672
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Soumis le : jeudi 15 octobre 2020 - 10:15:57
Dernière modification le : mercredi 18 novembre 2020 - 15:29:43

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Mansour Latreche, Jean-François Willart, Laurent Paccou, Yannick Guinet, Florence Danede, et al.. Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP. European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2020, European Journal of Pharmaceutics and Biopharmaceutics, 154, pp.222-227. ⟨10.1016/j.ejpb.2020.07.012⟩. ⟨hal-02967672⟩

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