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Article Dans Une Revue European Journal of Pharmaceutics and Biopharmaceutics Année : 2020

Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP

Résumé

A new method for determining solubility lines of drugs in polymers, based on low-frequency Raman spectroscopy measurements, is described and the results obtained by this method are compared with those obtained using a more classical method based on differential scanning calorimetry investigations. This method was applied to the paracetamol/PVP system using molecular and crystalline dispersions (MCD) rather than usual physical mixtures to reach faster the equilibrium saturated states and make the determination of the solubility line more rapid.
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Dates et versions

hal-02967672 , version 1 (15-10-2020)

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Citer

Mansour Latreche, Jean-François Willart, Laurent Paccou, Yannick Guinet, Florence Danede, et al.. Contribution of low-frequency Raman spectroscopy to determine the solubility curves of drugs in polymers: The case of paracetamol/PVP. European Journal of Pharmaceutics and Biopharmaceutics, 2020, European Journal of Pharmaceutics and Biopharmaceutics, 154, pp.222-227. ⟨10.1016/j.ejpb.2020.07.012⟩. ⟨hal-02967672⟩
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