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Manipulating the physical states of confined ibuprofen in SBA-15 based drug delivery systems obtained by solid-state loading: Impact of the loading degree

Abstract : Using the Milling-Assisted Loading (MAL) solid-state method for loading a poorly water-soluble drug (ibuprofen, IBP) within the SBA-15 matrix has given the opportunity to manipulate the physical state of drugs for optimizing bioavailability. The MAL method makes it easy to control and analyze the influence of the degree of loading on the physical state of IBP inside the SBA-15 matrix with an average pore diameter of 9.4 nm. It was found that the density of IBP molecules in an average pore size has a direct influence on both the glass transition and the mechanism of crystallization. Detailed analyzes of the crystallite distribution and melting by Raman mapping, x-ray diffraction, and differential scanning calorimetry have shown that the crystals are localized in the core of the channel and surrounded by a liquid monolayer. The results of these complementary investigations have been used for determining the relevant parameters (related to the SBA-15 matrix and to the IBP molecule) and the nature of the physical state of the confined matter.
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https://hal.univ-lille.fr/hal-02974158
Contributeur : Lilloa Université de Lille <>
Soumis le : vendredi 12 février 2021 - 15:31:04
Dernière modification le : jeudi 8 juillet 2021 - 14:48:01

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JCP20-AR-02616.pdf
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B. Malfait, Natália T. Correia, Carmen Ciotonea, Jérémy Dhainaut, Jean-Philippe Dacquin, et al.. Manipulating the physical states of confined ibuprofen in SBA-15 based drug delivery systems obtained by solid-state loading: Impact of the loading degree. Journal of Chemical Physics, American Institute of Physics, 2020, 153 (15), pp.154506. ⟨10.1063/5.0020992⟩. ⟨hal-02974158v2⟩

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