Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Gasotransmitters in Gametogenesis and Early Development: Holy Trinity for Assisted Reproductive Technology—A Review

Abstract : Creation of both gametes, sperm and oocyte, and their fusion during fertilization are essential step for beginning of life. Although molecular mechanisms regulating gametogenesis, fertilization, and early embryonic development are still subjected to intensive study, a lot of phenomena remain unclear. Based on our best knowledge and own results, we consider gasotransmitters to be essential for various signalisation in oocytes and embryos. In accordance with nitric oxide (NO) and hydrogen sulfide (H2S) physiological necessity, their involvement during oocyte maturation and regulative role in fertilization followed by embryonic development have been described. During these processes, NO- and H2S-derived posttranslational modifications represent the main mode of their regulative effect. While NO represent the most understood gasotransmitter and H2S is still intensively studied gasotransmitter, appreciation of carbon monoxide (CO) role in reproduction is still missing. Overall understanding of gasotransmitters including their interaction is promising for reproductive medicine and assisted reproductive technologies (ART), because these approaches contend with failure of in vitro assisted reproduction.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.univ-lille.fr/hal-03160179
Contributeur : Lilloa Université de Lille <>
Soumis le : vendredi 5 mars 2021 - 08:41:00
Dernière modification le : mardi 9 mars 2021 - 03:32:11

Fichier

1730750.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Collections

Citation

Jan Nevoral, Jean-Francois Bodart, Jaroslav Petr. Gasotransmitters in Gametogenesis and Early Development: Holy Trinity for Assisted Reproductive Technology—A Review. Oxidative Medicine and Cellular Longevity, Hindawi, 2016, 2016, pp.1730750. ⟨10.1155/2016/1730750⟩. ⟨hal-03160179⟩

Partager

Métriques

Consultations de la notice

8

Téléchargements de fichiers

7