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Carnitine alkyl ester bromides as novel biosourced ionic liquids, cationic hydrotropes and surfactants

Abstract : Hypothesis In contrast to anionic and nonionic amphiphilic substances, bio-based cationic ones are very rare. Cationic amphiphiles are mostly based on quaternary ammonium, pyridinium or imidazolium groups that are either badly biodegradable or have toxic residues even after degradation. In the search for green alternatives to cationic hydrotropes and amphiphiles, natural l-carnitine could be a promising candidate for a cationic headgroup. Experiments By esterification of carnitine in one step and with low cost, cationic molecules with alkyl chain length of n = 2–14 could be obtained. Their thermal properties, aggregation behaviour and cytotoxicity were determined. Hydrophobic compounds were solubilized in their aqueous solutions and the PIT-slope method was applied to determine a relative hydrophilicity. Findings It was found that some pure carnitine ester bromides were liquid at room temperature and thus can be classified as ionic liquids. They are highly water-soluble, and in aqueous solutions, they showed hydrotrope or surfactant behaviour depending on their alkyl chain length. Their high hydrotropic efficiency was demonstrated by solubilizing Disperse Red 13, while also biomolecules, like vanillin, could be dissolved in reasonable amounts. In all tests, they performed at least as good as the tested reference substances, while showing similar cytotoxicity towards human skin keratinocytes, thus demonstrating their potential as green functional amphiphilic molecules of positive charge.
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Soumis le : lundi 15 mars 2021 - 16:55:45
Dernière modification le : mercredi 3 novembre 2021 - 09:06:29




Katharina Häckl, Andrea Mühlbauer, Jesus Ontiveros Ontiveros, Sinisa Marinkovic, Boris Estrine, et al.. Carnitine alkyl ester bromides as novel biosourced ionic liquids, cationic hydrotropes and surfactants. Journal of Colloid and Interface Science, Elsevier, 2018, Journal of Colloid and Interface Science, 511, pp.165-173. ⟨10.1016/j.jcis.2017.09.096⟩. ⟨hal-03169842⟩



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