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Article Dans Une Revue Physical Review E : Statistical, Nonlinear, and Soft Matter Physics Année : 2013

Fokker-Planck description of single nucleosome repositioning by dimeric chromatin remodelers

Résumé

Recent experiments have demonstrated that the ATP-utilizing chromatin assembly and remodeling factor (ACF) is a dimeric, processive motor complex which can move a nucleosome more efficiently towards longer flanking DNA than towards shorter flanking DNA strands, thereby centering an initially ill-positioned nucleosome on DNA substrates. We give a Fokker-Planck description for the repositioning process driven by transitions between internal chemical states of the remodelers. In the chemical states of ATP hydrolysis during which the repositioning takes place a power stroke is considered. The slope of the effective driving potential is directly related to ATP hydrolysis and leads to the unidirectional motion of the nucleosome-remodeler complex along the DNA strand. The Einstein force relation allows us to deduce the ATP-concentration dependence of the diffusion constant of the nucleosome-remodeler complex. We have employed our model to study the efficiency of positioning of nucleosomes as a function of the ATP sampling rate between the two motors which shows that the synchronization between the motors is crucial for the remodeling mechanism to work.
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Dates et versions

hal-03172871 , version 1 (17-05-2021)

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Yves Vandecan, Ralf Blossey. Fokker-Planck description of single nucleosome repositioning by dimeric chromatin remodelers. Physical Review E : Statistical, Nonlinear, and Soft Matter Physics, 2013, Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics, 88 (1), pp.012728. ⟨10.1103/PhysRevE.88.012728⟩. ⟨hal-03172871⟩

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