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Self-regulatory gene: an exact solution for the gene gate model

Abstract : The stochastic dynamics of gene expression is often described by highly abstract models involving only the key molecular actors DNA, RNA, and protein, neglecting all further details of the transcription and translation processes. One example of such models is the "gene gate model," which contains a minimal set of actors and kinetic parameters, which allows us to describe the regulation of a gene by both repression and activation. Based on this approach, we formulate a master equation for the case of a single gene regulated by its own product-a transcription factor-and solve it exactly. The obtained gene product distributions display features of mono- and bimodality, depending on the choice of parameters. We discuss our model in the perspective of other models in the literature.
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Soumis le : mardi 18 mai 2021 - 17:36:47
Dernière modification le : mardi 18 mai 2021 - 17:45:31


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Yves Vandecan, Ralf Blossey. Self-regulatory gene: an exact solution for the gene gate model. Physical Review E : Statistical, Nonlinear, and Soft Matter Physics, American Physical Society, 2013, 87 (4), pp.042705. ⟨10.1103/PhysRevE.87.042705⟩. ⟨hal-03172878⟩



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