O-acetylated Gangliosides as Targets for Cancer Immunotherapy - Université de Lille Accéder directement au contenu
Article Dans Une Revue Cells Année : 2020

O-acetylated Gangliosides as Targets for Cancer Immunotherapy

Résumé

O-acetylation of sialic acid residues is one of the main modifications of gangliosides, and modulates ganglioside functions. O-acetylation of gangliosides is dependent on sialyl-O-acetyltransferases and sialyl-O-acetyl-esterase activities. CAS1 Domain-Containing Protein 1 (CASD1) is the only human sialyl-O-acetyltransferases (SOAT) described until now. O-acetylated ganglioside species are mainly expressed during embryonic development and in the central nervous system in healthy adults, but are re-expressed during cancer development and are considered as markers of cancers of neuroectodermal origin. However, the specific biological roles of O-acetylated gangliosides in developing and malignant tissues have not been extensively studied, mostly because of the requirement of specific approaches and tools for sample preparation and analysis. In this review, we summarize our current knowledge of ganglioside biosynthesis and expression in normal and pathological conditions, of ganglioside O-acetylation analysis and expression in cancers, and of the possible use of O-acetylated gangliosides as targets for cancer immunotherapy.
Fichier principal
Vignette du fichier
cells-09-00741-v2.pdf (1.03 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03179134 , version 1 (24-03-2021)

Licence

Paternité

Identifiants

Citer

Sumeyye Cavdarli, Philippe Delannoy, Sophie Groux. O-acetylated Gangliosides as Targets for Cancer Immunotherapy. Cells, 2020, 9 (3), pp.741. ⟨10.3390/cells9030741⟩. ⟨hal-03179134⟩

Collections

CNRS UNIV-LILLE
15 Consultations
80 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More