Ultrasensitive MAPK/Erk activation in absence of protein synthesis in Xenopus oocytes - Université de Lille
Article Dans Une Revue MAP Kinase Année : 2013

Ultrasensitive MAPK/Erk activation in absence of protein synthesis in Xenopus oocytes

Résumé

The mitogen-activated protein kinase (MAPK) cascade in Xenopus oocytes exhibits an all-or-none, ultrasensitive response, which is believed to result from a positive feed-back loop. Here we describe a context where 1,10-phenanthroline slowly, but strongly, activates MAPK while it impairs protein synthesis in a zincdependent manner, abolishing any feed-back loop. The induced-MAPK response was found to be strongly ultrasensitive. We argue that underlying this behaviour is a regulation motif akin to a feed-forward loop acting in vivo.
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hal-03204017 , version 1 (21-04-2021)

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Rémy Beaujois, Franck Riquet, Katia Cailliau-Maggio, Edith Browaeys-Poly, Christophe Russo, et al.. Ultrasensitive MAPK/Erk activation in absence of protein synthesis in Xenopus oocytes. MAP Kinase, 2013, 2 (1), pp.e2. ⟨10.4081/mk.2013.e2⟩. ⟨hal-03204017⟩

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