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Article dans une revue

Seven Solutions for Neuroprotection in Parkinson's Disease

Abstract : Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra and accumulation of iron and alpha-synuclein; it follows a characteristic pattern throughout the nervous system. Despite decades of successful preclinical neuroprotective studies, no drug has then shown efficacy in clinical trials. Considering this dilemma, we have reviewed and organized solutions of varying importance that can be exclusive or additive, and we outline approaches to help generate successful development of neuroprotective drugs for PD: (1) select patients in which the targeted mechanism is involved in the pathological process associated with the monitoring of target engagement, (2) combine treatments that target multiple pathways, (3) establish earliest interventions and develop better prodromal biomarkers, (4) adopt rigorous methodology and specific disease-relevant designs for disease-modifying clinical trials, (5) customize drug with better brain biodistribution, (6) prioritize repurposed drugs as a first line approach, and (7) adapt preclinical models to the targeted mechanisms with translational biomarkers to increase their predictive value. © 2020 International Parkinson and Movement Disorder Society
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https://hal.univ-lille.fr/hal-03261732
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Soumis le : mercredi 16 juin 2021 - 08:22:11
Dernière modification le : mardi 13 juillet 2021 - 03:28:13
Archivage à long terme le : : vendredi 17 septembre 2021 - 18:10:15

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David Devos, Etienne Hirsch, Richard Wyse. Seven Solutions for Neuroprotection in Parkinson's Disease. Movement Disorders, Wiley, 2021, 36 (2), pp.306-316. ⟨10.1002/mds.28379⟩. ⟨hal-03261732⟩

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