The present research focuses on the combined modeling and experimental work on the pyrolysis and oxidation of oxymethylene ethers (OMEs). OMEs are a family of molecules with alternating carbon and oxygen atoms in the backbone saturated with hydrogen atoms, represented with structural formula CH3O(CH2O)nCH3 (further indicated as OME-n). These molecules have interesting properties for applications as alternative fuel. OMEs are categorized as e-fuels since they can be produced in a carbon-neutral manner via carbon capture and utilization (CCU) starting from captured CO2 and renewable energy. In addition, blending them with conventional diesel reduces toxic soot emissions, due to the absence of carbon-carbon bonds, while still being compatible with the current generation of diesel engines. OMEs could as such contribute to the development of a more sustainable transport sector within the near future, and a circular carbon economy in general. However, before being widely applicable, it is important to fully understand the pyrolysis and oxidation chemistry of these compounds and their interactions with hydrocarbons. Therefore, a new microkinetic model is developed based on first principles that describes the low- and high-temperature decomposition pathways of oxymethylene ethers up to OME-5. This model enables predictive simulations for combustion applications.