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Article dans une revue

Chiral Quantum Metamaterial for Hypersensitive Biomolecule Detection

Abstract : Chiral biological and pharmaceutical molecules are analyzed with phenomena that monitor their very weak differential interaction with circularly polarized light. This inherent weakness results in detection levels for chiral molecules that are inferior, by at least six orders of magnitude, to the single molecule level achieved by state-of-the-art chirally insensitive spectroscopic measurements. Here, we show a phenomenon based on chiral quantum metamaterials (CQMs) that overcomes these intrinsic limits. Specifically, the emission from a quantum emitter, a semiconductor quantum dot (QD), selectively placed in a chiral nanocavity is strongly perturbed when individual biomolecules (here, antibodies) are introduced into the cavity. The effect is extremely sensitive, with six molecules per nanocavity being easily detected. The phenomenon is attributed to the CQM being responsive to significant local changes in the optical density of states caused by the introduction of the biomolecule into the cavity. These local changes in the metamaterial electromagnetic environment, and hence the biomolecules, are invisible to “classical” light-scattering-based measurements. Given the extremely large effects reported, our work presages next generation technologies for rapid hypersensitive measurements with applications in nanometrology and biodetection.
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https://hal.univ-lille.fr/hal-03518891
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Soumis le : lundi 10 janvier 2022 - 11:11:42
Dernière modification le : vendredi 1 avril 2022 - 03:44:14

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Maryam Hajji, Michele Cariello, Cameron Gilroy, Martin Kartau, Christopher D. Syme, et al.. Chiral Quantum Metamaterial for Hypersensitive Biomolecule Detection. ACS Nano, American Chemical Society, 2021, ACS Nano, 15 (12), pp.19905-19916. ⟨10.1021/acsnano.1c07408⟩. ⟨hal-03518891⟩

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