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Article Dans Une Revue ACS Nano Année : 2021

Chiral Quantum Metamaterial for Hypersensitive Biomolecule Detection

Maryam Hajji
  • Fonction : Auteur
Michele Cariello
  • Fonction : Auteur
Cameron Gilroy
  • Fonction : Auteur
Martin Kartau
  • Fonction : Auteur
Christopher D. Syme
  • Fonction : Auteur
Affar Karimullah
  • Fonction : Auteur
Nikolaj Gadegaard
  • Fonction : Auteur
Graeme Cooke
  • Fonction : Auteur
William J. Peveler
  • Fonction : Auteur
Malcolm Kadodwala
  • Fonction : Auteur

Résumé

Chiral biological and pharmaceutical molecules are analyzed with phenomena that monitor their very weak differential interaction with circularly polarized light. This inherent weakness results in detection levels for chiral molecules that are inferior, by at least six orders of magnitude, to the single molecule level achieved by state-of-the-art chirally insensitive spectroscopic measurements. Here, we show a phenomenon based on chiral quantum metamaterials (CQMs) that overcomes these intrinsic limits. Specifically, the emission from a quantum emitter, a semiconductor quantum dot (QD), selectively placed in a chiral nanocavity is strongly perturbed when individual biomolecules (here, antibodies) are introduced into the cavity. The effect is extremely sensitive, with six molecules per nanocavity being easily detected. The phenomenon is attributed to the CQM being responsive to significant local changes in the optical density of states caused by the introduction of the biomolecule into the cavity. These local changes in the metamaterial electromagnetic environment, and hence the biomolecules, are invisible to “classical” light-scattering-based measurements. Given the extremely large effects reported, our work presages next generation technologies for rapid hypersensitive measurements with applications in nanometrology and biodetection.
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Dates et versions

hal-03518891 , version 1 (08-12-2023)

Identifiants

Citer

Maryam Hajji, Michele Cariello, Cameron Gilroy, Martin Kartau, Christopher D. Syme, et al.. Chiral Quantum Metamaterial for Hypersensitive Biomolecule Detection. ACS Nano, 2021, ACS Nano, 15 (12), pp.19905-19916. ⟨10.1021/acsnano.1c07408⟩. ⟨hal-03518891⟩
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