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Article Dans Une Revue Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi Année : 2021

Potential role of tocilizumab in severe gastrointestinal barrier damage after car t-cell therapy

Résumé

We report a septicemia and disseminated candidiasis due to delayed gastrointestinal mucosae repair in a patient treated with tocilizumab after anti-CD19 CAR T-cell therapy. Tocilizumab could have inhibited intestinal tissue repair and furthered bacteria translocation leading to the invasion of intestinal mucosa by yeasts as IL-6 is known to be involved in mucosal wound healing.

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hal-03533922 , version 1 (09-05-2023)

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Paternité - Pas d'utilisation commerciale

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David Beauvais, Oriane Karleskind, Severine Loridant, Remy Nyga, Marie Lamiaux, et al.. Potential role of tocilizumab in severe gastrointestinal barrier damage after car t-cell therapy. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 2021, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 54 (2), pp.327-330. ⟨10.1016/j.jmii.2021.02.006⟩. ⟨hal-03533922⟩
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