A clay-based TiO2 nanocomposite material was synthesized by a facile method to investigate its structure and photocatalytic efficiency. The supported TiO2 nanoparticles were generated from a sol-gel method, and subsequently, mixed with a suspension of sepiolite. The material was recovered in powder form (Mc-80), and then calcined to properly arrange the crystal lattice of the TiO2 particles for use in heterogeneous photocatalysis (Mc-80-500). The powder X-ray diffractogram of Mc-80-500 reveals a dispersion of anatase and rutile phase TiO2 particles on the clay surface, exhibiting a size in the order of 4-8 nm. TEM images of Mc-80-500 confirmed the presence of isolated TiO2 beads on the surface of the fibrous sepiolite. The specific surface area of Mc-80-500 is larger than that of raw sepiolite and that of free TiO2 nanoparticles.Mc-80-500 was found to be more efficient in heterogeneous photocatalysis compared to other TiO2 materials based on sepiolite. A total depollution of a reactive dye (Orange G) was achieved after 1h irradiation time, which is relatively quick compared to previous reports. The photocatalyst material can be washed with distilled water without chemical additives or calcination, and can be reused several times for photocatalysis without loss of efficiency.