Cocrystals are molecular solids that are neutral crystalline single-phase materials composed oftwo or more different molecular compounds associated via weak supramolecular interactions such as van der Waals, hydrogen, halogen or π-π stacking. Cocrystals have shown a considerable increase of interest in recent years due to their possibility to improve many properties of pharmaceuticals (API) such as aqueous solubility, dissolution rate, hygroscopicity bioavailability, or mechanical properties.In this work, we aim to demonstrate that cocrystals may offer a new type of interestingconfinement environments including the possibilitty to investigate rotational and translationaldynamics in a true nanometric size channel-like architecture. Some results will be presented based on complementary Broadband Dielectric Spectroscopy, Powder X-ray Diffraction and 1H-13C CP/MAS solid-state NMR experiments combined with Molecular Dynamics simulations.