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Article Dans Une Revue Biochimica et Biophysica Acta - Molecular Cell Research Année : 2009

Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation

Résumé

The physiological role, the mechanisms of activation. as well as the endogenous regulators for the nonselective cationic channel TRPV2 are not known so far. In the present work we report that endogenous lysophospholipids such as lysophosphatidylcholine (LPC) and lysophosphatidylinositol (LPI) induce a calcium influx via TRPV2 channel. This activation is dependent on the length of the side-chain and the nature of the lysophospholipid head-group. TRPV2-mediated calcium uptake stimulated by LPC and LPI occurred via Gq/Go-protein and phosphatidylinositol-3,4 kinase (PI3,4K) signalling. We have shown that the mechanism of TRPV2 activation induced by LPC and LPI is due to the TRPV2 channel translocation to the plasma membrane. The activation of TRPV2 channel by LPC and LPI leads to an increase in the cell migration of the prostate cancer cell line PC3. We have demonstrated that TRPV2 is directly involved in both steady-state and lysophospholipid-stimulated cancer cell migration. Thus, for the first time, we have identified one of the natural regulators of TRPV2 channel, one of the mechanisms of TRPV2 activation and regulation, as well as its pathophysiological role in cancer.

Dates et versions

hal-04039097 , version 1 (21-03-2023)

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Michaël Monet, Dimitra Gkika, V'Yacheslav Lehen'Kyi, Albin Pourtier, Fabien Vanden Abeele, et al.. Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochimica et Biophysica Acta - Molecular Cell Research, 2009, 1793 (3), pp.528-539. ⟨10.1016/j.bbamcr.2009.01.003⟩. ⟨hal-04039097⟩
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