Radicalization leading to violence is a major societal issue all over the globe. In order to prevent its increase and expansion, measures need to be taken at different instances and levels. In the present narrative review, to inform evidence-based practices, we bring together numerous applied recommendations made by scholars studying the psychological underpinnings of radicalization within the framework of the Significance Quest Theory and its 3N model. The applied recommendations target at least one of the three elements of the 3N model (i.e., need, narrative, and network) in at least one of the three levels of prevention (i.e., primary, secondary, and tertiary). In the discussion, we highlight which of these are still lacking empirical evaluation, which might be problematic and why, and how policymakers, practitioners, and researchers can work together to provide an integrative model of intervention addressing both the need for significance and the influence of radical narratives and groups.