Purpose: To evaluate two agents for bonding denture bases and teeth manufactured either by stereolithography (SLA) or by the subtractive mixed technique. Methods: Two types of cylinders [small for the tooth resin and large for the base resin) were designed using CAD software according to the ANSI/ADA 15-2008 (R2013)] specification. For SLA manufacturing, 30 small cylinders were shaped with Denture Teeth resin and 30 large cylinders with Denture Base resin. For the mixed technique, 30 large cylinders were manufactured by SLA with V-print dentbase resin, and 30 small cylinders were milled with a CediTEC DT disk. Half the specimens were bonded with liquid Denture Base resin and half with CediTEC Primer and Adhesive, according to the manufacturers' protocols. Shear bond strength was measured using a universal testing machine. The failure mode was noted for all the specimens. Results: The shear bond strength values were not significantly different between the groups (P> 0.05). Specimens bonded with liquid Denture Base resin displayed cohesive failure (P> 0.05, ײ= 0). Of the specimens bonded with CediTEC Primer and Adhesive, cohesive failures were observed with five specimens manufactured with the SLA technique and one specimen manufactured with the mixed technique (P> 0.05, ײ= 3.33). The Chi-square test results were significant between groups with different bonding agents regardless of the technique used (P< 0.001). Within the limitations of the present study, even if the shear bond strength values were similar, the failure mode analysis suggests that the uncured liquid Denture Base resin may be more effective than the CediTEC Primer and Adhesive for bonding denture bases and teeth manufactured either by SLA or the mixed technique. Clinical significance: The present study suggests that the uncured liquid resin (Denture Base) used as a bonding agent and the denture base and tooth materials (V-Print and CediTEC DT) manufactured by SLA and the subtractive technique are clinically compatible.