Hansen Solubility Parameters (HSP) have been shown to be an effective approach for rationalizing and predicting the stability of titanium dioxide nanoparticles (TiO2 NPs) dispersions. However, interparticle electrostatic interactions, not considered in Hansen’s approach but taken into account in the DLVO theory, are expected to play a significant role in organic solvents having a notable dielectric constant. Zeta potential ζ of TiO2 P25 NPs was measured in both aqueous and organic media to identify DLVO-stabilized dispersions from those stabilized by more specific NP-solvent interaction. Stability was quantified using a Turbiscan optical device which provides Stokes diameters and Relative Turbiscan Stability Index (RTSI). When the zeta potential of NPs and the dielectric constant of the solvent are both high, the dispersion benefits from additional stabilization while when the electrostatic repulsion is negligible, only the solvents within a Hansen dispersion sphere give stable dispersions. The two interpretations are therefore complementary to describe the behavior of TiO2 dispersions in organic solvents.