Visible-light-driven carboxylic amine protocol (clap) for the synthesis of 2-substituted piperazines under batch and flow conditions - Université de Lille
Article Dans Une Revue Organic Letters Année : 2020

Visible-light-driven carboxylic amine protocol (clap) for the synthesis of 2-substituted piperazines under batch and flow conditions

Résumé

Piperazines are privileged scaffolds in medicinal chemistry. Disclosed herein is a visible-light-promoted decarboxylative annulation protocol between a glycine-based diamine and various aldehydes to access 2-aryl, 2-heteroaryl, as well as 2-alkyl piperazines. The iridium-based complex [Ir(ppy)2(dtbpy)]PF6 and carbazolyl dicyanobenzene 4CzIPN were found to be the photocatalysts of choice to efficiently perform the transformation under mild conditions, whether in batch or in continuous mode.

Domaines

Catalyse
Fichier principal
Vignette du fichier
Clap article.pdf (906.94 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04312599 , version 1 (28-11-2023)

Identifiants

Citer

Robin Gueret, Lydie Pelinski, Till Bousquet, Mathieu Sauthier, Vincent Ferey, et al.. Visible-light-driven carboxylic amine protocol (clap) for the synthesis of 2-substituted piperazines under batch and flow conditions. Organic Letters, 2020, Organic Letters, 22 (13), pp.5157-5162. ⟨10.1021/acs.orglett.0c01759⟩. ⟨hal-04312599⟩
12 Consultations
40 Téléchargements

Altmetric

Partager

More