Development of Adaptive Immunity and Its Role in Lung Remodeling.
Résumé
Asthma is characterized by airflow limitations resulting from bronchial closure, which can be either reversible or fixed due to changes in airway tissue composition and structure, also known as remodeling. Airway remodeling is defined as increased presence of mucins-producing epithelial cells, increased thickness of airway smooth muscle cells, angiogenesis, increased number and activation state of fibroblasts, and extracellular matrix (ECM) deposition. Airway inflammation is believed to be the main cause of the development of airway remodeling in asthma. In this chapter, we will review the development of the adaptive immune response and the impact of its mediators and cells on the elements defining airway remodeling in asthma.
Mots clés
Humans
Airway Remodeling
Lung
Asthma
Extracellular Matrix
Adaptive Immunity
Adaptive immunity
Airway smooth muscle
Allergen
Cytokine
Dendritic cell
Eosinophil
Epithelial cell
Extracellular matrix (ECM)
Fibroblast
Innate lymphoid cell
Lung remodeling
Lymphocyte
Mast cell
Matrix metalloproteinase
Mucins
Neutrophil
Domaines
Sciences du Vivant [q-bio]
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Development of Adapt IR and its role in lung remodel - BC 2023.pdf (1.1 Mo)
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