This chapter deals with smart textiles based on cyclodextrins (CDs) for curative or preventive patient care. CDs are topologically represented as toroids in which the openings expose the hydroxyl groups. As consequence, hydroxyl residues can be easily modified to introduce reactive groups and perform grafting onto fibers. Moreover, the interior of the toroid is sufficiently hydrophobic to host nonpolar medications (eg, antibiotics, antiinflammatory, insecticides, insect repellents, essential oils, phlebotonics). Upon complexation, the drug bioavailability is modified and sustainable controlled release can be obtained for dermal or transdermal treatment. In this chapter, the general features of CDs and their attachment techniques to the fabric's surface are reviewed. Finally, their applications and some future directions of investigation for the development of new functionalized textile products with advanced properties are presented.