Ruxolitinib before allogeneic hematopoietic transplantation in patients with myelofibrosis on behalf sfgm-tc and fim groups - Université de Lille Accéder directement au contenu
Article Dans Une Revue Bone Marrow Transplantation Année : 2021

Ruxolitinib before allogeneic hematopoietic transplantation in patients with myelofibrosis on behalf sfgm-tc and fim groups

Laure Vincent
  • Fonction : Auteur

Résumé

This multicenter prospective phase 2 trial analyzed disease-free survival (DFS) in myelofibrosis patients receiving ruxolitinib for 6 months before transplantation. Seventy-six patients were recruited. Age-adjusted dynamic international prognostic scoring system was intermediate-1, intermediate-2, and high in 27 (36%), 31 (41%), and 18 (24%) patients. All patients received ruxolitinib from inclusion to conditioning regimen (fludarabine-melphalan) or to progression. A donor was found in 64 patients: 18 HLA-matched sibling donor (MSD), 32 HLA-matched unrelated (UD10/10), and 14 HLA mismatched unrelated donor (UD9/10. Among 64 patients with a donor, 20 (31%) achieved a partial response before transplantation and 59 (92%) could be transplanted after ruxolitinib therapy (18/18 MSD, 30/21 UD10/10, 11/34 UD9/10), of whom 19 (32%) were splenectomized. Overall survival from inclusion was 68% at 12 months. One-year DFS after transplantation was 55%: 83%, 40%, and 34% after MSD, UD10/10 or UD9/10, respectively. Cumulative incidence of grade 2-4 acute graft-versus-host disease (GVHD) was 66% and non-relapse-mortality was 42% at 12 months. Short course of ruxolitinib before transplantation is followed by a high rate of transplantation. With the platform used in this protocol, outcome was much better in patients transplanted with HLA-matched sibling donor as compared to unrelated donor.

Dates et versions

hal-04408918 , version 1 (29-04-2024)

Identifiants

Citer

Marie Robin, Raphael Porcher, Corentin Orvain, Jacques-Olivier Bay, Fiorenza Barraco, et al.. Ruxolitinib before allogeneic hematopoietic transplantation in patients with myelofibrosis on behalf sfgm-tc and fim groups. Bone Marrow Transplantation, 2021, Bone Marrow Transplantation, 56, pp.1888-1899. ⟨10.1038/s41409-021-01252-7⟩. ⟨hal-04408918⟩
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