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Article Dans Une Revue Bulletin du Cancer Année : 2019

Second allogeneic hematopoietic stem cell transplant: Guidelines from the francophone Society of bone marrow transplantation and cellular therapy (SFGM-TC).

Nabil Yafour
  • Fonction : Auteur
Marie-Anne Couturier
  • Fonction : Auteur
Stephane Girault
  • Fonction : Auteur
Stavroula Masouridi-Levrat
  • Fonction : Auteur
Mauricette Michallet
  • Fonction : Auteur
Pascaline Etancelin
  • Fonction : Auteur
Thierry Guillaume
  • Fonction : Auteur
Florent Malard
  • Fonction : Auteur
Anne Sirvent
  • Fonction : Auteur
Xavier Poire
  • Fonction : Auteur

Résumé

Disease recurrence and graft dysfunction after allogeneic hematopoietic stem cell transplantation (allo-HSCT) currently remain among the major causes of treatment failure in malignant and non-malignant hematological diseases. A second allo-HSCT is a valuable therapeutic option to salvage those situations. During the 8th annual harmonization workshops of the french Society of bone marrow transplantation and cellular therapy (SFGM-TC), a designated working group reviewed the literature in order to elaborate unified guidelines on feasibility, indications, donor choice and conditioning in the case of a second allo-HSCT. In case of relapse, a second allo-HSCT with reduced intensity or non-myeloablative conditioning is a reasonable option, particularly in patients with a good performance status (Karnofsky/Lansky>80%), low co-morbidity score (EBMT score6 months), and who present low disease burden at the time of second allo-HSCT. Matched related donors tend to be associated with better outcomes. In the presence of graft dysfunction (primary and secondary graft rejection), an immunoablative conditioning regimen is recommended. A donor change remains a valid option, especially in the absence of graft-versus-host disease after the first allo-HSCT.
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Dates et versions

hal-04411306 , version 1 (23-01-2024)

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Citer

Nabil Yafour, Marie-Anne Couturier, Saba Azarnoush, Stephane Girault, Eric Hermet, et al.. Second allogeneic hematopoietic stem cell transplant: Guidelines from the francophone Society of bone marrow transplantation and cellular therapy (SFGM-TC).. Bulletin du Cancer, 2019, Bulletin du Cancer, 106, pp.S40-S51. ⟨10.1016/j.bulcan.2018.05.018⟩. ⟨hal-04411306⟩
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