Improved tissue integrity after alginate treatment in rat spinal cord injury: evidence from ex vivo diffusion tensor imaging.
Résumé
Diffusion tensor imaging (DTI) is a magnetic resonance imaging technique used to characterize fibrous structures such as white matter in the central nervous system, including normal and
spinal cord injury (SCI) conditions. Our aim was to evaluate the effect of alginate treatment in the
rat SCI by DTI parametric measures. Ex vivo DTI data were collected by spin echo sequence with
following parameters TR/TE: 2500 ms/32 ms and b-value of 1500 s/mm2
. Main significant changes
were found in fractional anisotropy (FA), and radial diffusivity (RD), between the saline- and alginatetreated group at the level of individual sections and whole spinal cord. Results indicate that ex vivo
DTI can be used as a tool for tissue structure characterisation and both FA and RD as promising
prognostic parameters of SCI treatment.
Domaines
Sciences du Vivant [q-bio]| Origine | Fichiers éditeurs autorisés sur une archive ouverte |
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