The impact of concomitant cytogenetic abnormalities on acute myeloid leukemia with monosomy 7 or deletion 7q after hla-matched allogeneic stem cell transplantation - Université de Lille Accéder directement au contenu
Article Dans Une Revue American Journal of Hematology Année : 2020

The impact of concomitant cytogenetic abnormalities on acute myeloid leukemia with monosomy 7 or deletion 7q after hla-matched allogeneic stem cell transplantation

Xavier Poire
  • Fonction : Auteur
Liisa Volin
  • Fonction : Auteur
Jurgen Finke
  • Fonction : Auteur
Arnold Ganser
  • Fonction : Auteur
Didier Blaise
Dietrich Beelen
  • Fonction : Auteur
Edouard Forcade
  • Fonction : Auteur
Bruno Lioure
  • Fonction : Auteur
Gerard Socie
  • Fonction : Auteur
Dietger Niederwieser
  • Fonction : Auteur
Helene Labussiere-Wallet
  • Fonction : Auteur
Johan Maertens
  • Fonction : Auteur
Jan J. Cornelissen
  • Fonction : Auteur
Charles Craddock
  • Fonction : Auteur
Jordi Esteve
  • Fonction : Auteur
Arnon Nagler
  • Fonction : Auteur

Résumé

Monosomy 7 or deletion 7q (-7/7q-) is the most frequent adverse cytogenetic features reported in acute myeloid leukemia (AML), and is a common indication for allogeneic stem cell transplantation (SCT). Nevertheless, -7/7q- occurs frequently with other high-risk cytogenetic abnormalities such as complex karyotype (CK), monosomal karyotype (MK), monosomy 5 or deletion 5q (-5/5q-), 17p abnormalities (abn(17p)) or inversion of chromosome 3 (inv(3)), the presence of which may influence the outcomes after SCT. A total of 1109 patients were allocated to this study. Two-year probability of leukemia-free survival (LFS) and overall survival (OS) were 30% and 36%, respectively. Two-year probability of non-relapse mortality (NRM) was 20%. We defined five different cytogenetic subgroups: the "-7/7q- ± CK group- designated group1," the "MK group-designated group 2," the "-5/5q- group- designated group 3," the "abn(17p) group- designated group 4" and the "inv(3) group- designated group 5." The 2-year probability of LFS in first remission was 48% for group 1, 36.4% for group 2, 28.4% for group 3, 19.1% for group 4 and 17.3% for group 5, respectively (P < .001). Multivariate analysis confirmed those significant differences across groups. Note, SCT in -7/7q- AML provides durable responses in one third of the patients. The presence of -7/7q- with or without CK in the absence of MK, abn(17p) or inv(3) is associated with a better survival after SCT. On the contrary, addition of MK, -5/5q-, abn(17p) or inv(3) identifies a sub-group of patients with poor prognosis even after SCT.

Dates et versions

hal-04426847 , version 1 (30-01-2024)

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Citer

Xavier Poire, Myriam Labopin, Emmanuelle Polge, Liisa Volin, Jurgen Finke, et al.. The impact of concomitant cytogenetic abnormalities on acute myeloid leukemia with monosomy 7 or deletion 7q after hla-matched allogeneic stem cell transplantation. American Journal of Hematology, 2020, American Journal of Hematology, 95, pp.282-294. ⟨10.1002/ajh.25714⟩. ⟨hal-04426847⟩
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