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Article Dans Une Revue (Article De Synthèse) Microorganisms Année : 2020

Enteroviral Pathogenesis of Type 1 Diabetes: The Role of Natural Killer Cells.

Résumé

Enteroviruses, especially group B coxsackieviruses (CV-B), have been associated with the development of chronic diseases such as type 1 diabetes (T1D). The pathological mechanisms that trigger virus-induced autoimmunity against islet antigens in T1D are not fully elucidated. Animal and human studies suggest that NK cells response to CV-B infection play a crucial role in the enteroviral pathogenesis of T1D. Indeed, CV-B-infected cells can escape from cytotoxic T cells recognition and destruction by inhibition of cell surface expression of HLA class I antigen through non-structural viral proteins, but they can nevertheless be killed by NK cells. Cytolytic activity of NK cells towards pancreatic beta cells persistently-infected with CV-B has been reported and defective viral clearance by NK cells of patients with T1D has been suggested as a mechanism leading to persistence of CV-B and triggering autoimmunity reported in these patients. The knowledge about host antiviral defense against CV-B infection is not only crucial to understand the susceptibility to virus-induced T1D but could also contribute to the design of new preventive or therapeutic approaches for individuals at risk for T1D or newly diagnosed patients.
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hal-04445722 , version 1 (08-02-2024)

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Magloire Pandoua Nekoua, Arthur Dechaumes, Famara Sane, Enagnon Kazali Alidjinou, Kabirou Moutairou, et al.. Enteroviral Pathogenesis of Type 1 Diabetes: The Role of Natural Killer Cells.. Microorganisms, 2020, Microorganisms, 8 (7), pp.989. ⟨10.3390/microorganisms8070989⟩. ⟨hal-04445722⟩

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