Does control of glycemia regulate immunological parameters in insulin-treated persons with type 1 diabetes? - Université de Lille
Article Dans Une Revue Diabetes Research and Clinical Practice Année : 2019

Does control of glycemia regulate immunological parameters in insulin-treated persons with type 1 diabetes?

Résumé

Aims We investigated the relationships between control of glycemia and the frequencies of immune cell subpopulations and also the profile of circulating T cell cytokines in insulin-treated persons with type 1 diabetes (T1D). Methods Clinical data and blood samples were collected from two groups of persons with T1D exhibiting either adequate (AGC) or inadequate glycemic control (IGC), as well as from individuals without diabetes considered as a control group. Serum cytokine levels and immune cell subpopulation frequencies were determined. Results Irrespective of their capacity to control glycemia, the percentages of effector CD4+ T-cells and CD19+ B-cells were higher in persons with T1D than in controls, whilst monocytes were significantly more frequent in those with IGC than in controls. The overall frequencies of CD4+ T-cells, CD8+ T-cells and Foxp3+CD4+CD25+ regulatory T-cells did not differ between the three groups. The serum levels of IL-2 and IFN-γ were lower in both groups with T1D compared to controls, whilst the level of IL-4 did not differ. The level of IL-10 was significantly lower in those with AGC compared to controls. Conclusion Our study shows that insulin treatment is associated with a Th2-biased systemic immune phenotype in persons with T1D, reflected by a high proportion of effector CD4+ T cells and CD19+ B cells and a down-regulation of Th1-type serum cytokines.
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Dates et versions

hal-04454670 , version 1 (13-02-2024)

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Magloire Pandoua Nekoua, Rufine Fachinan, Adnette Fagninou, Enagnon Kazali Alidjinou, Kabirou Moutairou, et al.. Does control of glycemia regulate immunological parameters in insulin-treated persons with type 1 diabetes?. Diabetes Research and Clinical Practice, 2019, Diabetes Research and Clinical Practice, 157, pp.107868. ⟨10.1016/j.diabres.2019.107868⟩. ⟨hal-04454670⟩

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