Low Serum Levels of Interferon Alpha in COVID-19 Patients Are Associated with Older Age. - Université de Lille Accéder directement au contenu
Article Dans Une Revue Journal of Clinical Medicine Année : 2022

Low Serum Levels of Interferon Alpha in COVID-19 Patients Are Associated with Older Age.

Résumé

Innate immune response, especially type 1 interferon (IFN) response is considered to play a substantial role in the outcome of SARS-CoV-2 infection. A reduced and delayed IFN response has been associated with progression to severe COVID-19. In this study, we investigated levels of circulating IFNα and serum neutralizing activity in COVID-19 patients admitted to the intensive care unit. We found a significant association of levels of IFNα with age (p = 0.007). This association has also been observed in a cohort of COVID-19 outpatients with mild infection (p = 0.02). The impact of senescence on IFN response can explain the higher susceptibility of the elderly to severe COVID-19.
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hal-04456645 , version 1 (14-02-2024)

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Enagnon Kazali Alidjinou, Mickael Hirabidian, Anthony Rabat, Mahdi Ouafi, Magloire Pandoua Nekoua, et al.. Low Serum Levels of Interferon Alpha in COVID-19 Patients Are Associated with Older Age.. Journal of Clinical Medicine, 2022, Journal of Clinical Medicine, 11, pp.961. ⟨10.3390/jcm11040961⟩. ⟨hal-04456645⟩

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