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Article Dans Une Revue (Article De Synthèse) Advanced drug delivery reviews Année : 2021

Clinical translation of advanced colonic drug delivery technologies

Résumé

Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local diseases, direct access to unique therapeutic targets and the potential for increasing systemic drug bioavailability and efficacy. Although a range of traditional colonic delivery technologies are available, these systems exhibit inconsistent drug release due to physiological variability between and within individuals, which may be further exacerbated by underlying disease states. In recent years, significant translational and commercial advances have been made with the introduction of new technologies that incorporate independent multi-stimuli release mechanisms (pH and/or microbiota-dependent release). Harnessing these advanced technologies offers new possibilities for drug delivery via the colon, including the delivery of biopharmaceuticals, vaccines, nutrients, and microbiome therapeutics for the treatment of both local and systemic diseases. This review details the latest advances in colonic drug delivery, with an emphasis on emerging therapeutic opportunities and clinical technology translation.

Dates et versions

hal-04462343 , version 1 (16-02-2024)

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Citer

Atheer Awad, Christine M. Madla, Laura E. Mccoubrey, Fabiana Ferraro, Francesca K. H. Gavins, et al.. Clinical translation of advanced colonic drug delivery technologies. Advanced drug delivery reviews, 2021, Advanced Drug Delivery Reviews, 181, pp.114076. ⟨10.1016/j.addr.2021.114076⟩. ⟨hal-04462343⟩

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