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Article Dans Une Revue Cancers Année : 2021

High Prevalence of 5T4/Trophoblast Glycoprotein in Soft Tissue Sarcomas

P. Groothuis
  • Fonction : Auteur
N. Kotecki
  • Fonction : Auteur
F. Dijcks
  • Fonction : Auteur
W. Dokter
  • Fonction : Auteur

Résumé

The expression of 5T4/trophoblast glycoprotein was evaluated in several histological subtypes of soft tissue sarcoma (STS) to determine whether the prevalence and level of expression of this membrane-associated glycoprotein is sufficient for use in targeted therapies. Tumor tissue microarrays containing cores from different histological subtypes of STS were stained using a standardized immunohistochemical staining method to detect 5T4; the level of staining was assessed using a semi-quantitative scoring method. No 5T4 staining was seen in the angiosarcomas and liposarcomas investigated in this study. 5T4 staining in the other STS subtypes was seen in more than 50% of cases, warranting further investigation into whether this antigen could evoke an anti-tumor immune response or can be used as target for the delivery of more potent toxins through antibody drug conjugates.
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hal-04472423 , version 1 (22-02-2024)

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P. Groothuis, Nicolas Penel, A. Italiano, N. Kotecki, F. Dijcks, et al.. High Prevalence of 5T4/Trophoblast Glycoprotein in Soft Tissue Sarcomas. Cancers, 2021, Cancers, 13, pp.4841. ⟨10.3390/cancers13194841⟩. ⟨hal-04472423⟩

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