Diffusion Controlled Drug Delivery Systems - Université de Lille
Chapitre D'ouvrage Année : 2019

Diffusion Controlled Drug Delivery Systems

Résumé

This chapter presents an overview on the different types of drug delivery systems that are predominantly governed by diffusion. The systems are classified according to their physical structure (reservoir devices versus monolithic systems), as well as according to the ratio of “initial drug loading and drug solubility.” For various cases, mathematical models are briefly presented considering different device geometries. These theories are mechanistically realistic and enable quantitative description of the resulting release kinetics. Effects of formulation parameters on drug release can also be predicted quantitatively. Practical examples are given to illustrate the applicability of the presented theories and the benefits of understanding how a diffusion-controlled drug delivery system works.
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Dates et versions

hal-04474666 , version 1 (23-02-2024)

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Juergen Siepmann, Ronald A. Siegel, Florence Siepmann. Diffusion Controlled Drug Delivery Systems. Siepmann, Juergen; Siegel, Ronald A.; Rathbone, Michael J. Fundamentals and Applications of Controlled Release Drug Delivery, -, Springer Link, pp.127-152, 2019, 978-1-4614-0881-9. ⟨10.1007/978-1-4614-0881-9_6⟩. ⟨hal-04474666⟩

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