Impact of kidney transplantation in obese candidates: a time-dependent propensity score matching study. - Université de Lille
Article Dans Une Revue Nephrol Dial Transplant Année : 2022

Impact of kidney transplantation in obese candidates: a time-dependent propensity score matching study.

Résumé

Background Although kidney transplantation (KT) is considered the best treatment for end-stage renal disease (ESRD), there are concerns about its benefit in the obese population because of the increased incidence of post-transplant adverse events. We compared patients who underwent KT versus patients awaiting KT on dialysis. Methods We estimated the life expectancy [restricted mean survival time (RMST)] for a 10-year follow-up by matching on time-dependent propensity scores. The primary outcome was time to death. Results In patients with a body mass index (BMI) ≥30 kg/m2 (n = 2155 patients per arm), the RMST was 8.23 years [95% confidence interval (CI) 8.05–8.40] in the KT group versus 8.00 years (95% CI 7.82–8.18) in the awaiting KT group, a difference of 2.71 months (95% CI −0.19–5.63). In patients with a BMI ≥35 kg/m2 (n = 212 patients per arm), we reported no significant difference [8.56 years (95% CI 7.96–9.08) versus 8.66 (95% CI 8.10–9.17)]. Hence we deduced that KT in patients with a BMI between 30 and 35 kg/m2 was beneficial in terms of life expectancy. Conclusion Regarding the organ shortage, KT may be questionable for those with a BMI ≥35 kg/m2. These results do not mean that a BMI ≥35 kg/m2 should be a barrier to KT, but it should be accounted for in allocation systems to better assign grafts and maximize the overall life expectancy of ESRD patients.
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Dates et versions

hal-04481444 , version 1 (28-02-2024)

Identifiants

Citer

Christel Castelli, Yohann Foucher, Julie Boucquemont, Mathilde Prezelin-Reydit, Magali Giral, et al.. Impact of kidney transplantation in obese candidates: a time-dependent propensity score matching study.. Nephrol Dial Transplant, 2022, Nephrol Dial Transplant, 37 (9), pp.1768-1776. ⟨10.1093/ndt/gfac152⟩. ⟨hal-04481444⟩
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