Carfilzomib, lenalidomide and dexamethasone followed by a second ASCT is an effective strategy in first relapse multiple myeloma: a study on behalf of the Chronic malignancies working party of the EBMT. - Université de Lille
Article Dans Une Revue Bone Marrow Transplantation Année : 2023

Carfilzomib, lenalidomide and dexamethasone followed by a second ASCT is an effective strategy in first relapse multiple myeloma: a study on behalf of the Chronic malignancies working party of the EBMT.

1 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
2 LIRIC - Lille Inflammation Research International Center - U 995
3 Universiteit Leiden = Leiden University
4 LUMC - Leiden University Medical Center
5 Chemnitz University of Technology / Technische Universität Chemnitz
6 Radboud University Medical Center [Nijmegen]
7 Hospital Universitario Reina Sofía de Córdoba
8 Eberhard Karls Universität Tübingen = University of Tübingen
9 Uniklinik - Universitäts Klinikum Freiburg = University Medical Center Freiburg
10 UMCU - University Medical Center [Utrecht]
11 UKSH - University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein
12 Cardiff University
13 IGR - Institut Gustave Roussy
14 Universidad de Salamanca [España] = University of Salamanca [Spain]
15 UCLH - University College London Hospitals
16 UKA - Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany]
17 University Hospital Hamburg-Eppendorf
18 Hospital Clínico Universitario Virgen de la Arrixaca = University Hospital Virgen de la Arrixaca [Murcia]
19 Fondazione Policlinico Universitario Agostino Gemelli IRCCS
20 Trinity College Dublin
21 Ankara University School of Medicine [Turkey]
22 UCLH - University College London Hospitals NHS Foundation Trust [London, UK]
23 Heidelberg University Hospital [Heidelberg]
24 CANTHER - Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277
Christine Schuermans
  • Fonction : Auteur
Mariagrazia Michieli
  • Fonction : Auteur

Résumé

In the setting of a first relapse of multiple myeloma (MM), a second autologous stem cell transplant (ASCT) following carfilzomib-lenalidomide-dexamethasone (KRd) is an option, although there is scarce data concerning this approach. We performed a retrospective study involving 22 EBMT-affiliated centers. Eligible MM patients had received a second-line treatment with KRd induction followed by a second ASCT between 2016 and 2018. Primary objective was to estimate progression-free survival (PFS) and overall survival (OS). Secondary objectives were to assess the response rate and identify significant variables affecting PFS and OS. Fifty-one patients were identified, with a median age of 62 years. Median PFS after ASCT was 29.5 months while 24- and 36-months OS rates were 92.1% and 84.5%, respectively. Variables affecting PFS were an interval over four years between transplants and the achievement of a very good partial response (VGPR) or better before the relapse ASCT. Our study suggests that a relapse treatment with ASCT after KRd induction is an effective strategy for patients with a lenalidomide-sensitive first relapse. Patients with at least four years of remission after a frontline ASCT and who achieved at least a VGPR after KRd induction appear to benefit the most from this approach.
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hal-04514753 , version 1 (21-03-2024)

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Remi Tilmont, Ibrahim Yakoub-Agha, Diderik-Jan Eikema, Nienke Zinger, Mathias Haenel, et al.. Carfilzomib, lenalidomide and dexamethasone followed by a second ASCT is an effective strategy in first relapse multiple myeloma: a study on behalf of the Chronic malignancies working party of the EBMT.. Bone Marrow Transplantation, 2023, Bone Marrow Transplantation, ⟨10.1038/s41409-023-02048-7⟩. ⟨hal-04514753⟩
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