Factors of loss to follow-up during tuberculosis treatment in a low-incidence region - Université de Lille
Article Dans Une Revue Médecine et Maladies Infectieuses Année : 2019

Factors of loss to follow-up during tuberculosis treatment in a low-incidence region

Résumé

OBJECTIVE: The proportion of successfully treated tuberculosis (TB) patients remains below the WHO target in France, because of a high proportion of loss to follow-up. We aimed to identify factors associated with loss to follow-up in northern France, a low-incidence area. METHODS: Between 1997 and 2017, all consecutive patients diagnosed with TB at the Tourcoing Hospital, except those infected with multidrug-resistant or extensively drug-resistant strains, were included in a retrospective cohort study. A logistic regression analysis was performed to determine factors associated with loss to follow-up. RESULTS: One hundred and ninety patients were included. Previous TB treatment was reported in 32 patients (17%), extrapulmonary TB in 107 (56%), and HIV infection in 44 (23%). The proportion of loss to follow-up was 15%. In multivariate analysis, the risk of loss to follow-up decreased in case of first TB treatment (OR 0.36; 95% CI: 0.14-0.92, P=0.03) and increased in non-HIV-infected patients (OR 7.67; 95% CI: 1.00-59.0, p=0.05). Support for compliance was more frequent in HIV-infected patients (23% vs. 7%, p=0.005). CONCLUSIONS: The proportion of loss to follow-up was high. HIV infection was associated with a lower risk of loss to follow-up, likely to be due to more frequent support for compliance.
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Dates et versions

hal-04523160 , version 1 (27-03-2024)

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M. Tetart, Agnes Meybeck, A. Assaf, Michel Valette, P. Choisy, et al.. Factors of loss to follow-up during tuberculosis treatment in a low-incidence region. Médecine et Maladies Infectieuses, 2019, Médecine et Maladies Infectieuses, 50 (1), pp.28-35. ⟨10.1016/j.medmal.2019.02.007⟩. ⟨hal-04523160⟩

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