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Article Dans Une Revue European Journal of Obstetrics & Gynecology and Reproductive Biology Année : 2021

Changes in S100B and troponin levels in a fetal sheep model of worsening acidosis

Résumé

Background S100B and cardiac troponin T (c-TnT) are relevant biomarkers at birth of hypoxic-ischemic encephalopathy (HIE) and myocardial ischemia secondary to metabolic acidosis during labor, respectively. The purpose was to assess in-utero changes in S100B and c-TnT levels in an experimental model of labor-like acidosis. Methods Repeated umbilical cord occlusions (UCOs) in ten experiments were performed in mild (phase A, 1 UCO/5 mn), moderate (phase B, 1 UCO/3 mn), and severe (phase C, 1 UCO/2 mn) period. The experiments were stopped if arterial pH reached 6.90. Results UCOs resulted in fetal acidosis with pH dropping to 6.99 ± 0.13. When compared to the baseline period fetal S100B increased between phases A and B (7% ± 4 vs 17% ± 13, p = 0.030) and between phases A and C (7% ± 4 vs 24% ± 8, p < 0.001). Fetal c-TnT serum levels increased during occlusions: 102 ng/L (58–119) in phase A, vs 119 ng/L (103–198) in phase B vs 169 ng / L (128–268) in phase C (p < 0.05, for all). When compared to the baseline control period, fetal ΔcTnT was significantly modified throughout UCO series: 5.0% (-3; 45) in phase A, 51% (4; 263) in phase B, and 77% (56.5; 269) in phase C (p < 0.05 for all). Conclusions S100B and c-TnT increased when fetal acidosis occurred, which reflects the potential neurological damage and fetal cardiovascular adaptation. Keywords

Dates et versions

hal-04540490 , version 1 (10-04-2024)

Identifiants

Citer

Yasmine Ould Hamoud, J. D. Pekar, Elodie Drumez, Laure Lacan, Patrice Maboudou, et al.. Changes in S100B and troponin levels in a fetal sheep model of worsening acidosis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 2021, European Journal of Obstetrics & Gynecology and Reproductive Biology, 264, p. 173-177. ⟨10.1016/j.ejogrb.2021.06.042⟩. ⟨hal-04540490⟩

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