Synthesis and Characterization of 3-Methylene Isoindolinones by Two Synthetic Routes - Université de Lille
Article Dans Une Revue Polycyclic Aromatic Compounds Année : 2021

Synthesis and Characterization of 3-Methylene Isoindolinones by Two Synthetic Routes

Résumé

The aim of this study was a detailed examination of the synthesis of 3-methyleneisoindolinones comprising various functional groups. Methylmagnesuim bromide and PTSA was employed for the synthesis of these compounds. A wide range of 3-methyleneisoindolinones were afforded in good to excellent yields. On the other hand, 3-methyleneisoindolinones was also obtained by an efficient microwave method. The frame work of these derivatives was constructed from 2- acetylbenzoic acid and various primary amines via two-component reaction. The obtained compounds were characterized by 1H NMR, 13C-NMR and IR and elemental analysis.
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Dates et versions

hal-04548244 , version 1 (16-04-2024)

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Hamida Jelali, Lamjed Mansour, Jameel Al-Tamimi, Eric Deniau, Mathieu Sauthier, et al.. Synthesis and Characterization of 3-Methylene Isoindolinones by Two Synthetic Routes. Polycyclic Aromatic Compounds, 2021, Polycyclic Aromatic Compounds, pp.1-13. ⟨10.1080/10406638.2021.1971269⟩. ⟨hal-04548244⟩
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