Comparison of biomarker for diagnosis of nitrous oxide abuse: challenge of cobalamin metabolic parameters, a retrospective study. - Université de Lille
Article Dans Une Revue Journal of Neurology Année : 2023

Comparison of biomarker for diagnosis of nitrous oxide abuse: challenge of cobalamin metabolic parameters, a retrospective study.

Isabelle Kim
  • Fonction : Auteur
Jean Claude Guichard
  • Fonction : Auteur
Marie Girot
  • Fonction : Auteur
Linda Humbert
  • Fonction : Auteur
Vincent Chieux
  • Fonction : Auteur
Audrey Joly
  • Fonction : Auteur
Phénicia Nasserdine
  • Fonction : Auteur
Nathalie Trillot
  • Fonction : Auteur

Résumé

Background Recreational use of nitrous oxide (N2O) leads to neurological disorders including combined subacute degeneration of spinal cord, psychological disorders, and thrombosis. Serum or urine N2O assays could not be routinely performed. Hence, it is necessary to investigate other biological markers such as metabolic markers. We aimed here to challenge the three main biological markers used for the diagnosis of nitrous oxide abuse as total vitamin B12, homocysteine, and methylmalonic acid. Methods We retrospectively collected clinical and biological data from 52 patients with known, documented chronic N2O abuse and associated clinical signs (peripheral neuropathy disability score or thrombosis event). Sera and plasma total vitamin B12, methylmalonic acid (MMA), and homocysteine were performed to identify the most specific marker of chronic N2O intoxication and related clinical outcomes. Results Plasma homocysteine was almost consistently increased in case of N2O chronic consumption, whereas MMA increase and total vitamin B12 decrease are not systematically found. Our results showed that none of the markers are correlated with levels of N2O consumptions. However, homocysteine and MMA are correlated with clinical severity, but MMA seems to be a better marker of clinical severity. Conclusion There is no specific marker of nitrous oxide abuse according to levels of consumption, total vitamin B12 decrease could not be used either as consumption or as severity marker. However, we showed that homocysteine is consistently increased and could be used as marker of recent N2O consumption. On the other hand, we showed that MMA could be used as a marker of clinical gravity.
Fichier non déposé

Dates et versions

hal-04550978 , version 1 (18-04-2024)

Identifiants

Citer

Guillaume Grzych, Sylvie Deheul, Emeline Gernez, Jean-Baptiste Davion, Dries Dobbelaere, et al.. Comparison of biomarker for diagnosis of nitrous oxide abuse: challenge of cobalamin metabolic parameters, a retrospective study.. Journal of Neurology, 2023, Journal of Neurology, ⟨10.1007/s00415-023-11570-z⟩. ⟨hal-04550978⟩
19 Consultations
0 Téléchargements

Altmetric

Partager

More