Selective Discrimination of Cyclodextrin Diols Using Cyclic Sulfates
Résumé
A method for selective monofunctionalition of readily available cyclodextrin diols (2A−F,3A−F,6B,C,E,F-hexadeca-O-benzyl-α-cyclodextrin and 2A−G,3A−G,6B,C,E−G-nonadeca-O-benzyl-β-cyclodextrin) by regioselective nucleophilic opening of their cyclic sulfates is presented. Although the A and D products are nonequivalent in β-cyclodextrin, only the A product is formed.