Racial differences in systemic sclerosis disease presentation: a european scleroderma trials and research group study - Université de Lille
Article Dans Une Revue Rheumatology Année : 2020

Racial differences in systemic sclerosis disease presentation: a european scleroderma trials and research group study

Veronika K. Jaeger
  • Fonction : Auteur
Mohammed Tikly
  • Fonction : Auteur
Dong Xu
  • Fonction : Auteur
Elise Siegert
  • Fonction : Auteur
Paolo Airo
  • Fonction : Auteur
Gabriele Valentini
  • Fonction : Auteur
Marco Matucci-Cerinic
  • Fonction : Auteur
Oliver Distler
  • Fonction : Auteur
Franco Cozzi
  • Fonction : Auteur
Patricia E. Carreira
  • Fonction : Auteur
Ulf Muller-Ladner
  • Fonction : Auteur
Lidia P. Ananieva
  • Fonction : Auteur
Alexandra Balbir-Gurman
  • Fonction : Auteur
Jorg H. W. Distler
  • Fonction : Auteur
Laszlo Czirjak
  • Fonction : Auteur
Mengtao Li
  • Fonction : Auteur
Jorg Henes
  • Fonction : Auteur
Sergio A. Jimenez
  • Fonction : Auteur
Vanessa Smith
  • Fonction : Auteur
Nemanja Damjanov
  • Fonction : Auteur
Christopher P. Denton
  • Fonction : Auteur
Francesco del Galdo
  • Fonction : Auteur
Lesley Ann Saketkoo
  • Fonction : Auteur
Ulrich A. Walker
  • Fonction : Auteur

Résumé

OBJECTIVE: Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations. METHODS: SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses. RESULTS: The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP. AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001]. CONCLUSIONS: Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality.
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Dates et versions

hal-04559430 , version 1 (25-04-2024)

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Citer

Veronika K. Jaeger, Mohammed Tikly, Dong Xu, Elise Siegert, Eric Hachulla, et al.. Racial differences in systemic sclerosis disease presentation: a european scleroderma trials and research group study. Rheumatology, 2020, Rheumatology, 59, ⟨10.1093/rheumatology/kez486⟩. ⟨hal-04559430⟩

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