Retinal Vascular Density Using Optical Coherence Tomography-Angiography in Optic Neuritis. - Université de Lille
Article Dans Une Revue Journal of Clinical Medicine Année : 2023

Retinal Vascular Density Using Optical Coherence Tomography-Angiography in Optic Neuritis.

Résumé

The aim of this study is to access the perifoveolar and peripapillary vascular density (VD) using optical coherence tomography-angiography (OCT-A) in eyes with optic neuritis (ON) and in fellow eyes, then compare that to healthy controls. Method: This is a cross-sectional study including 22 patients with unilateral ON and 20 control eyes of healthy subjects. A complete clinical examination and OCT-A were performed at least 6 months after the acute episode of optic neuritis. Vascular plexuses of the peripapillary and perifoveolar images obtained from OCT-A were used to calculate the VD in each plexus: superficial, deep, and peripapillary capillaries for each group (ON eyes, fellow eyes, healthy eyes). Results: Compared to healthy control eyes, in the peripapillary area, we found a significant decrease in VD not only in ON eyes but also in fellow eyes in average (p ≤ 0.05) and in the temporal sector (p < 0.001). In the perifoveolar area, the VD of the superficial capillary plexus is decreased in all sectors (p < 0.001) in ON eyes and only in the upper sector (p = 0.037) of fellow eyes compared to control eyes. VD correlates with ganglion cell layer (GCL) thickness in ON and in fellow eyes. Conclusion: Peripapillary vascular density is decreased in both affected eyes and fellow eyes after a unilateral episode of optic neuritis, suggesting a subclinical involvement of the disease. Further studies are needed to clarify the mechanism and clinical implications of these data.
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hal-04621381 , version 1 (24-06-2024)

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Paul Codron, Ines Masmoudi, Thi-Ha-Chau Tran. Retinal Vascular Density Using Optical Coherence Tomography-Angiography in Optic Neuritis.. Journal of Clinical Medicine, 2023, Journal of Clinical Medicine, 12 (16), pp.5403. ⟨10.3390/jcm12165403⟩. ⟨hal-04621381⟩

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