Prevalence and target attainment of traditional cardiovascular risk factors in patients with systemic lupus erythematosus: a cross-sectional study including 3401 individuals from 24 countries. - Université de Lille
Article Dans Une Revue The Lancet Rheumatology Année : 2024

Prevalence and target attainment of traditional cardiovascular risk factors in patients with systemic lupus erythematosus: a cross-sectional study including 3401 individuals from 24 countries.

Eleana Bolla
  • Fonction : Auteur
Anne Grete Semb
  • Fonction : Auteur
Anne M. Kerola
  • Fonction : Auteur
Eirik Ikdahl
  • Fonction : Auteur
Michelle Petri
  • Fonction : Auteur
Guillermo J. Pons-Estel
  • Fonction : Auteur
George A. Karpouzas
  • Fonction : Auteur
Petros P. Sfikakis
  • Fonction : Auteur
Rosana Quintana
  • Fonction : Auteur
Durga Prasanna Misra
  • Fonction : Auteur
Eduardo Ferreira Borba
  • Fonction : Auteur
Ignacio Garcia-de la Torre
  • Fonction : Auteur
Tatiana V. Popkova
  • Fonction : Auteur
Bahar Artim-Esen
  • Fonction : Auteur
Anne Troldborg
  • Fonction : Auteur
Hilda Fragoso-Loyo
  • Fonction : Auteur
Sofia Ajeganova
  • Fonction : Auteur
Ayten Yazici
  • Fonction : Auteur
Gustavo Aroca-Martinez
  • Fonction : Auteur
Haner Direskeneli
  • Fonction : Auteur
Manuel F. Ugarte-Gil
  • Fonction : Auteur
Marta Mosca
  • Fonction : Auteur
Mohit Goyal
  • Fonction : Auteur
Elisabeth Svenungsson
  • Fonction : Auteur
Carla Macieira
  • Fonction : Auteur
Alberta Hoi
  • Fonction : Auteur
Karoline Lerang
  • Fonction : Auteur
Angela Tincani
  • Fonction : Auteur
Erkin Mirrakhimov
  • Fonction : Auteur
Isabel Acosta Colman
  • Fonction : Auteur
Alvaro Danza
  • Fonction : Auteur
Loreto Massardo
  • Fonction : Auteur
Jelena Blagojevic
  • Fonction : Auteur
Neslihan Yılmaz
  • Fonction : Auteur
Dana Tegzová
  • Fonction : Auteur
Sule Yavuz
  • Fonction : Auteur
Cengiz Korkmaz
  • Fonction : Auteur
Mario J. Moreno Alvarez
  • Fonction : Auteur
Roberto Muñoz-Louis
  • Fonction : Auteur
Nikos Pantazis
  • Fonction : Auteur
Maria G. Tektonidou
  • Fonction : Auteur

Résumé

Background Systemic lupus erythematosus (SLE) is characterised by increased cardiovascular morbidity and mortality risk. We aimed to examine the prevalence of traditional cardiovascular risk factors and their control in an international survey of patients with systemic lupus erythematosus. Methods In this multicentre, cross-sectional study, cardiovascular risk factor data from medical files of adult patients (aged ≥18) with SLE followed between Jan 1, 2015, and Jan 1, 2020, were collected from 24 countries, across five continents. We assessed the prevalence and target attainment of cardiovascular risk factors and examined potential differences by country income level and antiphospholipid syndrome coexistence. We used the Systemic Coronary Risk Evaluation algorithm for cardiovascular risk estimation, and the European Society of Cardiology guidelines for assessing cardiovascular risk factor target attainment. People with lived experience were not involved in the research or writing process. Findings 3401 patients with SLE were included in the study. The median age was 43·0 years (IQR 33–54), 3047 (89·7%) of 3396 patients were women, 349 (10.3%) were men, and 1629 (48·1%) of 3390 were White. 556 (20·7%) of 2681 patients had concomitant antiphospholipid syndrome. We found a high cardiovascular risk factor prevalence (hypertension 1210 [35·6%] of 3398 patients, obesity 751 [23·7%] of 3169 patients, and hyperlipidaemia 650 [19·8%] of 3279 patients), and suboptimal control of modifiable cardiovascular risk factors (blood pressure [target of <130/80 mm Hg], BMI, and lipids) in the entire SLE group. Higher prevalence of cardiovascular risk factors but a better blood pressure (target of <130/80 mm Hg; 54·9% [1170 of 2132 patients] vs 46·8% [519 of 1109 patients]; p<0·0001), and lipid control (75·0% [895 of 1194 patients] vs 51·4% [386 of 751 patients], p<0·0001 for high-density lipoprotein [HDL]; 66·4% [769 of 1158 patients] vs 60·8% [453 of 745 patients], p=0·013 for non-HDL; 80·9% [1017 of 1257 patients] vs 61·4% [486 of 792 patients], p<0·0001 for triglycerides]) was observed in patients from high-income versus those from middle-income countries. Patients with SLE with antiphospholipid syndrome had a higher prevalence of modifiable cardiovascular risk factors, and significantly lower attainment of BMI and lipid targets (for low-density lipoprotein and non-HDL) than patients with SLE without antiphospholipid syndrome. Interpretation High prevalence and inadequate cardiovascular risk factor control were observed in a large multicentre and multiethnic SLE cohort, especially among patients from middle-income compared with high-income countries and among those with coexistent antiphospholipid syndrome. Increased awareness of cardiovascular disease risk in SLE, especially in the above subgroups, is urgently warranted. Funding None.
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Dates et versions

hal-04677823 , version 1 (26-08-2024)

Identifiants

Citer

Eleana Bolla, Anne Grete Semb, Anne M. Kerola, Eirik Ikdahl, Michelle Petri, et al.. Prevalence and target attainment of traditional cardiovascular risk factors in patients with systemic lupus erythematosus: a cross-sectional study including 3401 individuals from 24 countries.. The Lancet Rheumatology, 2024, The Lancet Rheumatology, 6, pp.e447-e459. ⟨10.1016/S2665-9913(24)00090-0⟩. ⟨hal-04677823⟩

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