Characterisation of airway disease associated with Sjögren disease. - Université de Lille
Article Dans Une Revue RMD Open : Rheumatic & Musculoskeletal Diseases Année : 2024

Characterisation of airway disease associated with Sjögren disease.

L. Meudec
  • Fonction : Auteur
M. P. Debray
  • Fonction : Auteur
A. Beurnier
  • Fonction : Auteur
C. Marques
  • Fonction : Auteur
P. A. Juge
  • Fonction : Auteur
R. Dhote
  • Fonction : Auteur
C. Larroche
  • Fonction : Auteur
A. L. Fauchais
  • Fonction : Auteur
E. Dernis
  • Fonction : Auteur
O. Vittecoq
  • Fonction : Auteur
A. Saraux
J. E. Gottenberg
  • Fonction : Auteur
V. Le Guern
  • Fonction : Auteur
P. Dieudé
  • Fonction : Auteur
R. Seror
  • Fonction : Auteur
X. Mariette
  • Fonction : Auteur
G. Nocturne
  • Fonction : Auteur

Résumé

Objective Although airway disease associated with Sjögren’s disease (Sjo-AD) is common, it is poorly studied compared with interstitial lung disease (ILD). In this study, we aimed to assess factors associated with Sjo-AD, the characteristics and prognosis of this manifestation. Methods We performed a retrospective multicentric study involving nine centres. We included Sjo-AD patients confirmed by at least one clinician and one CT scan report. Clinical and biological data, pulmonary function test (PFT), and CT scans were collected. A single radiologist specialist in thoracic diseases reviewed CT scans. Sjo-AD patients were compared with Sjo controls without pulmonary involvement, randomly selected after matching for age and disease duration. Results We included 31 Sjo-AD and 62 Sjo controls without pulmonary history. Sjo-AD had a higher disease activity (ESSDAI) compared with controls, even when excluding the pulmonary domain of the score (7 vs 3.8, p<0.05), mainly due to the biological activity. Sjo-AD was multilobar (72%) and associated with signs of both bronchiectasis and bronchiolitis (60%). Obstructive lung disease occurred in 32% at the time of Sjo-AD diagnosis. Overall, PFT was stable after 8.7±7 years follow-up but repeated CT scans showed extended lesions in 41% of cases within 6±3.2 years. No patient developed Sjo-ILD. Sjo-AD progression was independent of the global disease activity. Conclusions Sjo-AD preferentially affects Sjo patients with higher biological activity. It is often characterised as a diffuse disease, affecting both proximal and distal airways, with a slow evolution over time and no progression to Sjo-ILD.
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hal-04687055 , version 1 (04-09-2024)

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L. Meudec, M. P. Debray, A. Beurnier, C. Marques, P. A. Juge, et al.. Characterisation of airway disease associated with Sjögren disease.. RMD Open : Rheumatic & Musculoskeletal Diseases, 2024, RMD Open : Rheumatic & Musculoskeletal Diseases, 10, pp.e003866. ⟨10.1136/rmdopen-2023-003866⟩. ⟨hal-04687055⟩

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