Article Dans Une Revue (Article De Synthèse) Movement Disorders Clinical Practice Année : 2023

Predictors and Pathophysiology of Axial Postural Abnormalities in Parkinsonism: A Scoping Review.

1 UNITO - Università degli studi di Torino = University of Turin
2 UNIVR - Università degli studi di Verona = University of Verona
3 RadboudUMC - Radboud University Medical Center [Nijmegen]
4 University of Calgary
5 Safdarjung Hospital Campus
6 OHSU - Oregon Health and Science University [Portland]
7 Columbia University [New York]
8 Ruijin Hospital [Shanghai, Chine]
9 Shanghai Jiao Tong University School of Medicine
10 JUST - Jordan University of Science and Technology [Irbid, Jordan]
11 SBUMS - Shahid Beheshti University of Medical Sciences [Tehran]
12 CAU - Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel
13 FLENI - Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia [Buenos Aires]
14 USP - Universidade de São Paulo = University of São Paulo
15 Rabin Medical Center [Tel Aviv, Israël]
16 TAU - Tel Aviv University
17 Royal Victoria Hospital
18 QUB - Queen's University [Belfast]
19 University of Toronto
20 Krembil Research Institute
21 Toronto Western Hospital
22 Ibn Sina University Hospital [Rabat, Maroc]
23 UM5 - Université Mohammed V de Rabat [Agdal]
24 LilNCog - Lille Neurosciences & Cognition - U 1172
25 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
26 Fukushima University [Fukushima, Japan]
27 Chulalongkorn University [Bangkok]
28 King Chulalongkorn Memorial Hospital [Bangkok]
29 Thai Red Cross Society
30 Royal Society of Thailand [Bangkok, Thailand]
C. Aquino
  • Fonction : Auteur
V. T. Labou
  • Fonction : Auteur

Résumé

Background Postural abnormalities involving the trunk are referred to as axial postural abnormalities and can be observed in over 20% of patients with Parkinson's disease (PD) and in atypical parkinsonism. These symptoms are highly disabling and frequently associated with back pain and a worse quality of life in PD. Despite their frequency, little is known about the pathophysiology of these symptoms and scant data are reported about their clinical predictors, making it difficult to prompt prevention strategies. Objectives We conducted a scoping literature review of clinical predictors and pathophysiology of axial postural abnormalities in patients with parkinsonism to identify key concepts, theories and evidence on this topic. Methods We applied a systematic approach to identify studies, appraise quality of evidence, summarize main findings, and highlight knowledge gaps. Results Ninety-two articles were reviewed: 25% reported on clinical predictors and 75% on pathophysiology. Most studies identified advanced disease stage and greater motor symptoms severity as independent clinical predictors in both PD and multiple system atrophy. Discrepant pathophysiology data suggested different potential central and peripheral pathogenic mechanisms. Conclusions The recognition of clinical predictors and pathophysiology of axial postural abnormalities in parkinsonism is far from being elucidated due to literature bias, encompassing different inclusion criteria and measurement tools and heterogeneity of patient samples. Most studies identified advanced disease stage and higher burden of motor symptoms as possible clinical predictors. Pathophysiology data point toward many different (possibly non-mutually exclusive) mechanisms, including dystonia, rigidity, proprioceptive and vestibular impairment, and higher cognitive deficits.
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Dates et versions

hal-04779979 , version 1 (20-11-2024)

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C. A. Artusi, Christian Geroin, J. Nonnekes, C. Aquino, D. Garg, et al.. Predictors and Pathophysiology of Axial Postural Abnormalities in Parkinsonism: A Scoping Review.. Movement Disorders Clinical Practice, 2023, Movement Disorders Clinical Practice, 10 (11), pp.1585-1596. ⟨10.1002/mdc3.13879⟩. ⟨hal-04779979⟩

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