Real-world effectiveness of dupilumab in a European cohort of CRSwNP (CHRINOSOR). - Université de Lille
Article Dans Une Revue Journal of Allergy and Clinical Immunology Année : 2024

Real-world effectiveness of dupilumab in a European cohort of CRSwNP (CHRINOSOR).

S. F. Seys
  • Fonction : Auteur
S. Schneider
  • Fonction : Auteur
J. de Kinderen
  • Fonction : Auteur
S. Reitsma
  • Fonction : Auteur
C. Cavaliere
  • Fonction : Auteur
P. V. Tomazic
  • Fonction : Auteur
C. Morgenstern
  • Fonction : Auteur
M. Wagenmann
  • Fonction : Auteur
G. Bettio
  • Fonction : Auteur
A. Ciofalo
  • Fonction : Auteur
Z. Diamant
  • Fonction : Auteur
J. Eckl-Dorna
  • Fonction : Auteur
W. J. Fokkens
  • Fonction : Auteur
C. Holzmeister
  • Fonction : Auteur
G. Mariën
  • Fonction : Auteur
S. Masieri
  • Fonction : Auteur
J. Otten
  • Fonction : Auteur
K. Scheckenbach
  • Fonction : Auteur
A. Tu
  • Fonction : Auteur
C. Bachert
  • Fonction : Auteur

Résumé

Background Pivotal studies with dupilumab demonstrated clinically relevant improvements in nasal polyp score, symptom score, and quality-of-life score in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Objective We evaluated the effectiveness of dupilumab in a large-scale CRSwNP cohort from 6 European tertiary-care centers. Methodology Nasal polyp score, Sinonasal Outcome Test 22 score, visual analog scale for total sinus symptoms, loss of smell, and nasal blockage, and Asthma Control Test (ACT) score were collected from hospital records and assessed at baseline and again at 24 and 52 weeks’ treatment with dupilumab in CRSwNP patients. Treatment effectiveness was evaluated in relation to demographic and lifestyle factors, sinus surgery history, presence of comorbidities, and blood eosinophil counts (BEC). Treatment response was evaluated according to European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) 2021 criteria. Results All patient outcomes improved at 24 and 52 weeks’ treatment compared to baseline. Dupilumab showed effectiveness independent of age, sex, body mass index, smoking status, prior sinus surgery, presence of asthma, nonsteroidal anti-inflammatory drug–exacerbated respiratory disease, allergy, or baseline BEC. A total of 92.5% and 94.4% showed an improvement in at least 1 EUFOREA criterion at 24 and 52 weeks, respectively; 54.4% and 68.2% met all 4 of the more stringent EUFOREA criteria at 24 and 52 weeks, respectively. Conclusions Real-world evaluation of dupilumab effectiveness demonstrates a robust and sustained response in at least two thirds of patients at 52 weeks’ treatment. Favorable treatment response was independent of the number of sinus surgery procedures, major comorbidities, or baseline systemic levels of type 2 inflammation.
Fichier non déposé

Dates et versions

hal-04844675 , version 1 (18-12-2024)

Identifiants

Citer

S. F. Seys, S. Schneider, J. de Kinderen, S. Reitsma, C. Cavaliere, et al.. Real-world effectiveness of dupilumab in a European cohort of CRSwNP (CHRINOSOR).. Journal of Allergy and Clinical Immunology, 2024, Journal of Allergy and Clinical Immunology, ⟨10.1016/j.jaci.2024.10.016⟩. ⟨hal-04844675⟩

Collections

UNIV-LILLE
0 Consultations
0 Téléchargements

Altmetric

Partager

More